Upstage Raises $381.0M Series D

Craif Inc.

Craif is a molecular diagnostics company leveraging miRNA and machine learning for early cancer detection. Our proprietary platform, launched in Japan in 2022, powers the miSignal test, which screens for seven cancers (pancreatic, ovarian, esophageal, lung, breast, colorectal, and gastric) and has seen over 400% YoY revenue growth. In parallel with the commercialization of miSignal, we have started the clinical trial for the IVD test - pancreatic cancer diagnostic test for high risk population (e.g. diabetes, pancreatitis, etc.). This is a test seeking FDA/PMDA approval and planned to be reimbursed by insurance companies in the U.S. and reimbursed by the National Healthcare System in Japan. The clinical trial in Japan started in April 2024 and is planned to obtain approval in 2027H1. Craif USA was established in 2023 to bring this platform to the U.S. market, focusing on pancreatic cancer due to the high unmet need. We are currently enrolling cancers and high-risk controls to begin validation of the assay in a US population and are developing a US portfolio strategy that reflects the unmet clinical need and competitive landscape.

AraBat

AraBat is a deep-tech startup based in Delaware, US, and Italy, developing bio-based hydrometallurgical technologies for the sustainable recycling of lithium batteries and e-waste. Our proprietary process uses biomass-derived chemistry to recover critical raw materials, strategic metals and selected rare earth elements from complex waste streams, reducing the need for aggressive chemicals and offering a cleaner alternative to conventional recycling routes. AraBat’s mission is to transform waste into a new strategic resource for the energy transition, electric mobility, electronics, and industrial supply chains. By recovering materials such as lithium, cobalt, nickel, manganese, copper, precious metals and rare earth elements where present, we aim to strengthen raw material independence, support resilient supply chains, and reduce the environmental impact of primary extraction. We are building a new generation of recycling technologies where nature, chemistry and industrial innovation work together to give raw materials a second life. We are open to collaborations with investors, industrial partners, recyclers, manufacturers, and organizations committed to critical raw materials recovery, clean technologies and sustainable industrial innovation. E-mail: arabat.startup@gmail.com

Neuromorphic Labs

The Trust Layer for Production AI - Build and deploy your models and agents faster, with verifiable control at every stage. Runs in your environment. Works with the tools you already use.

Smack Technologies Inc.

Smack is building the first frontier AI lab for national security. Our mission is to deliver Decision Dominance to the U.S. DoW, its allies, and partners. Smack's domain-specific models analyze multimodal data streams in real time, converting that data into campaign-informed decisions across the kill chain in seconds.