Isometric Raises $400.0

Vitalis Ortho

Knee osteoarthritis affects over 365 million people worldwide. For the 37% of patients under 65-years-old, established clinical pathways have limited options between pain management and joint replacement. That leaves millions in a treatment gap facing a particularly difficult trade-off: undergo a knee replacement and face a lifetime revision risk of 1 in 3, or delay surgery and lose years of quality life. Olly Morgan and Mac Tuncer spent years operating at the end of that journey. Together, they scaled Meshworks Implants into the UK and Ireland’s leading provider of personalised, 3D-printed orthopaedic implants. The devices were designed for the most complex revision cases, where standard implants had already failed. They exited the business in 2024. That experience gave them an unusually clear view of what goes wrong upstream. Vitalis Ortho was founded on a single conviction that the window for meaningful intervention exists years before irreversible surgery becomes the only option. Our goal is to make joint preservation the default for younger patients, not the exception.

Astral Systems

Based in Bristol, UK, Astral Systems was founded in 2021. Our Multi-State Fusion (MSF) reactor is a versatile, compact, and cost-effective solution for on-demand neutron production. We leverage cutting-edge fusion discoveries out of NASA and are continually advancing the effectiveness of our MSF technology. We offer high-flux neutron sources for decentralised and scale medical isotope production, nuclear power applications, and much more. Our first Mk1 product is now available for order with a fusion neutron performance that has a 10x higher output and over 10x longer lifetime than any compact neutron source on the planet.

RQ Biotechnology Ltd.

RQ Biotechnology is making instant immunity a reality for vulnerable people. As the leading passive immunization discovery company, we partner with pharmaceutical companies to develop our antibodies into protect against infectious diseases where vaccines cannot. RQ Bio is dedicated to developing medicines based on potent broad-spectrum mAbs to provide instant and long-lasting protection for vulnerable people at risk of severe disease or death from current and future viral infections.

Omni Pet | B Corp™

Pet food is usually made from unwanted, unhealthy animal by-products from the CO2 polluting meat industry. But it doesn’t have to be this way, omni has created delicious, healthier and more sustainable plant-based dog food.

Silveray

Developing next generation direct conversion X-ray detectors for healthcare, industrial, and security applications.