Reply Next Raises $457.0K Pre-Seed Round

CONNECTA Therapeutics

CONNECTA Therapeutics is a clinical-stage biotech company leveraging its small-molecule neuroplasticity modulation platform to address unmet medical needs in Central Nervous System (CNS) disorders with a focus on pediatric neurodevelopmental conditions. Neuroplasticity is the ability of the nervous system to adapt its activity in response to intrinsic or extrinsic stimuli by reorganizing its structure, functions, and connections, and is impaired in the vast majority of these disorders. The Company’s lead program, CTH120, is a first-in-class disease-modifying modulator for Fragile X Syndrome (FXS), a rare and currently untreatable neurodevelopmental disorder that strongly impairs cognition and behavior. CTH120 is a small novel molecule that targets the tropomyosin receptor kinase B (TrkB), a key mediator in brain development and function. Unlike existing symptomatic treatments, CTH120 aims to restore the underlying neuronal architecture. Supported by robust preclinical data and Phase I clinical results (NCT06480968), CONNECTA is advancing CTH120 through a Phase II clinical trial in adults with FXS. In parallel, and with additional support from the FRAXCURE project (co-funded by the European Union), the company is preparing to expand development into pediatric populations. CONNECTA’s scalable neuroplasticity modulation platform has already yielded additional promising compounds that have shown potential in treating multiple CNS disorders. Preclinical models have demonstrated efficacy for FXS and Rett Syndrome, with the potential to address other high-value indications such as Down’s syndrome, DiGeorge syndrome, autism spectrum disorder (ASD), attention deficit hyperactivity disorder (ADHD), and neuropathic pain.

HVR energy

We are the Re-Evolution of energy. A company that focuses exclusively on generating green hydrogen with the aim of transforming people’s lives to move towards a better future. At HVR we are committed to developing hydrogen distributed generation projects. We offer solutions for mobility, heavy transport, logistics and industrial applications in which electrification cannot be achieved or is very difficult to achieve by other means.

Deneb Medical

Deneb Medical is a start-up based in Miramon, San Sebastian, focused in the development of new disruptive medical solutions. As part of its strategy Deneb is always looking for brilliant individuals who thrive with new technological challenges and are willing to explore new paths in science, technology and business