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A new entrant in the specialized field of gene construct engineering, Houdini Bio, has secured $1.9M in pre-seed funding. The round saw participation from SCVC, Deep Science Ventures, and Cambridge Enterprise Ventures.
Houdini Bio's core work involves engineering gene constructs specifically designed to escape existing performance limits, a focus that attracted this early-stage investment.
Houdini Bio has emerged from stealth with $1.95 million in pre-seed funding led by SCVC, with participation from Deep Science Ventures and Cambridge Enterprise Ventures, to develop a DNA engineering platform designed to improve the durability and effectiveness of gene therapies.
Founded in 2025, the British biotech startup combines machine learning with research into cellular DNA silencing mechanisms to help therapeutic genes evade biological defenses that can reduce treatment efficacy. The company says its platform can increase gene expression by more than tenfold compared to existing approaches, with potential applications across conditions including cystic fibrosis, ha
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Largest funding rounds in Biotechnology on Signalbase right now.
| # | Company | Round | Amount | Date |
|---|---|---|---|---|
| 1 |  Shockwave Medical United States | Unknown | $13.1B | 1y ago |
| 2 |  NeuroEM Therapeutics United States | Unknown | $7.2B | 1y ago |
| 3 |  GRAIL United States | Unknown | $7.1B | 1y ago |
| 4 |  Illumina United States | Unknown | $7.1B | 1y ago |
| 5 |  RemeGen Biosciences United States | Grant | $5.6B | 5mo ago |
Companies that recently closed a Pre-seed round.
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| 1 |  Edvisor Canada | Pre-seed | $1.3M | 1d ago |
| 2 |  reltix Germany | Pre-seed | $3.5M | 1d ago |
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| 4 |  MediaKits United States | Pre-seed | $1.0M | 2d ago |
| 5 |  PULSE 360 Program United States | Pre-seed | $100.0K | 3d ago |